Rubidium-82 has a long story, starting in 1954. After preclinical studies in dogs showing that myocardial uptake of this radionuclide was directly proportional to myocardial blood flow (MBF), clinical studies were …

On July 3, 2023, the U.S. Nuclear Regulatory Commission (NRC) solicited comments on the regulatory basis for the planned rulemaking on "Rubidium-82 Generators, Emerging Technologies, and Other Medical Use of Byproduct Material." The public comment period was originally scheduled to close on October 31, 2023.

Rubidium-82 (Rb-82) and nitrogen-13 (N-13) ammonia are clinically used PET perfusion tracers, whereas oxygen-15 (O-15) water is a research perfusion tracer. Rb-82 is the …

Rubidium-82 Generators and Emerging Medical Technologies," dated January 13, 2022 ... based requirements for existing EMTs based on operating experience,and (3) revise other outdated, prescriptive requirements with risk-informed, …

The 'Evidence based indications for the use of PET CT in the United Kingdom', recommend the use of both 13 N-ammonia and 82 Rb MPS as alternatives to SPECT. 34 Against this 82 Rb MPS is currently available in only two centres: at our institution and at University College Hospital, London.

Rubidium-82 (Rb-82) and nitrogen-13 (N-13) ammonia are clinically used PET perfusion tracers, whereas oxygen-15 (O-15) water is a research perfusion tracer. Rb-82 is the most commonly used PET perfusion tracer, with a half-life of 76 seconds, and is produced by a strontium-83 generator. ... The Rb-82 PI reports dosimetry values based on data ...

1429 Objectives Published radiation dose estimates for Rubidium-82 vary widely, and no comprehensive study in man has yet been conducted. With the increasing use of Rb-82 PET for myocardial perfusion imaging, improved dosimetry information is needed for accurate risk assessment. The purpose of this study was to measure Rb-82 internal …

We aimed to confirm the feasibility of RBF estimation based on positron emission tomography/ computed tomography (PET/CT) and rubidium-82 (⁸²Rb) using the abdominal aorta as input function in a ...

Hybrid cardiac positron emission tomography/computed tomography (PET/CT) with 82 rubidium (82 Rb) is a useful clinical tool for the diagnosis of unknown or suspected coronary arterial disease (CAD) and microvascular disease, improving the understanding of the pathophysiology of disease processes thus directly impacting the …

Precautions. Drug information provided by: Merative, Micromedex ®. It is very important that your doctor check your progress very closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. You might receive a medicine to make your ...

Rubidium chloride Rb-82 injection is a sterile nonpyrogenic solutions of rubidium Rb 82 chloride. It is indicated for Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic stress conditions to evaluate regional myocardial perfusion in adult patients with suspected or existing coronary artery disease.

The latter based on the indication that 82 Rb is primarily present in the plasma during the short duration of the dynamic PET/CT study [37, 38], as well as the observation that our previously measured 82 Rb clearance values (766 ± 114 ml/min/1.73 m 2) are similar to historically published values for ERPF [26, 39, 40].

Rubidium-82 ( 82 Rb) is a widely used positron emission tomography (PET) tracer with a short half-life of ~ 75 seconds. 1 Stress perfusion imaging with 82 Rb is used widely in cardiac PET centers for the assessment of known or suspected coronary artery …

Rubidium-82 is increasingly being used for cardiac PET imaging, but radiation dose estimates for the exams are based on old -- and conflicting -- data. Researchers from Johns Hopkins University offer updated dose estimates for rubidium-82 procedures in a study published in the October issue of the Journal of Nuclear Medicine.

Rubidium is an Unofficial Fork of CaffeineMC's "Sodium", made to work with Forge Mod Loader. Rubidium contains all the features of the classic Sodium. A modern OpenGL rendering pipeline for chunk rendering that takes advantage of multi-draw techniques, allowing for a significant reduction in CPU overhead (~90%) when rendering the world.

Rubidium-82. 82 Rb is produced from a strontium-82 ( 82 Sr)/ 82 Rb generator, which can be eluted every 10 minutes. 27 The T 1/2 of 82 Sr is 25.5 days, which results in a …

Rubidium-82. 82 Rb is produced from a strontium-82 ( 82 Sr)/ 82 Rb generator, which can be eluted every 10 minutes. 27 The T 1/2 of 82 Sr is 25.5 days, which results in a generator life of 6 to 8 weeks. The short T 1/2 of 82 Rb (76 seconds) allows repeated and sequential perfusion studies but requires rapid image acquisition shortly after ...

The RUBY-FILL® Rubidium Rb 82 Generator contains accelerator produced Strontium-82, which decays to Rubidium-82. When the generator is eluted with saline it produces a sterile, non-pyrogenic solution of Rb-82 Chloride used for Cardiac Positron Emission Tomography (PET), a non-invasive imaging procedure of the myocardium, to evaluate …

Background The most reliable quantitative variable on Rubidium-82 (82Rb) cardiac PET/CT for predicting major adverse cardiovascular events (MACE) has not been characterized with low-dose silicon photomultipliers (SiPM) technology, which allows halving injected activity and radiation dose delivering less than 1.0 mSv in a 70-kg individual. …

Conclusion. Measurement of renal perfusion based on PET/CT and 82 Rb using AA as input function in a 1-tissue compartment model is feasible in a single FOV. Based on previous studies showing 82 Rb to be primarily present in plasma, the measured K 1 clearance values are most likely representative of effective renal plasma flow (ERPF) …

Introduction. Rubidium-82 (82 Rb) is a widely used positron emission tomography (PET) tracer with a short half-life of ~ 75 seconds.1 Stress perfusion imaging with 82 Rb is used widely in cardiac PET centers for the assessment of known or suspected coronary artery disease.2 The short half-life of 82 Rb allows rapid sequential rest and …

The recommended weight-based dose of rubidium Rb 82 chloride to be administered per rest or stress component of a PET myocardial perfusion imaging (MPI) procedure is between 10-30 Megabecquerels (MBq)/kg [0.27-0.81 millicuries (mCi)/kg]. Do not exceed a single dose of 2220 MBq (60 mCi).

Dosage Forms And Strengths. CardioGen-82 is a closed system used to produce rubidium Rb 82 chloride injection for intravenous use. CardioGen-82 consists of strontium Sr-82 adsorbed on a hydrous stannic oxide column with an activity of 90-150 millicuries Sr-82 at calibration time.

Abstract. 1429. Objectives Published radiation dose estimates for Rubidium-82 vary widely, and no comprehensive study in man has yet been conducted. With the increasing use of …

Background Recent reports have demonstrated the clinical use of rubidium-82 chloride (Rb-82) in combination with positron emission tomography (PET) not only as a tracer of myocardial blood flow but also …

The regulatory basis, titled "Rubidium-82 Generators, Emerging Technologies, and Other Medical Use of Byproduct Material—Regulatory Basis," can be obtained at ADAMS Accession No. ML23122A356. ... The analyses are based on the NRC's preliminary assessment and estimates, and the NRC will conduct a more detailed …

Rubidium-82 (82 Rb) is a generator-produced PET myocardial perfusion tracer and has been widely used in North America in clinical practice. 82 Rb PET has recently become available in some cardiovascular centers in …

Rulemaking Plan to Establish Requirements for Rubidium-82 Generators and Emerging Medical Technologies," dated January 13, 2022 (ML22013A266). Discussion: On July 3, 2023, the NRC published a notice in the Federal Register announcing the availability of this regulatory basis document for a 120-day public comment period (see 88 FR 42654).

Purpose Quantification of myocardial blood flow (MBF) has become central in the clinical application of Rubidium-82 (82Rb) PET myocardial perfusion scans. Current recommendations suggest injections of 1100–1500 MBq of 82Rb in bolus form, which poses a potential risk of PET system saturation on most 3D PET/CT systems currently being …

Rubidium-82 has a long story, starting in 1954. ... Pooled patient-based sensitivity and specificity were, respectively, 0.91 and 0.90. By comparison with (99m)Tc-SPECT, (82)Rb PET had a much better diagnostic accuracy, especially in obese patients with body mass index ≥30 kg/m(2) (85 versus 67% with SPECT) and in women with …

Cardiogen-82 is a radionuclide generator of rubidium-82 (Rb-82) containing strontium-82 (Sr-82) adsorbed on stannic oxide in a chromatography column. It provides a means of obtaining, via elution, a sterile, non-pyrogenic injectable solution of …